代表性论文: [1] Gui-Rong Qu,* Hong-Liang Zhang, Hong-Ying Niu, Zai-Kun Xue, Xin-Xin Lv, Hai-Ming Guo*, Synthesis of C6-Azolyl Purine Nucleosides via C-N Coupling Reaction of Unprotected 6-Chloropurine Nucleosides and N-Heterocycles under Catalyst- and Solvent-Free Conditions, Green Chem, 2012, DOI: 10.1039/c0xx00000x. [2] Gui-Rong Qu,* Yan-Wei Song, Hong-Ying Niu, Hai-Ming Guo,* John S. Fossey, Cu(OTf)2-catalyzed Ritter reaction: Efficient synthesis of amides from nitriles and halohydrocarbons in water, RSC Adv, 2012, DOI:10.1039/C2RA20941A. [3] Peng-Yang Xin, Hong-Ying Niu, Gui-Rong Qu,* Rui-Fang Ding, Hai-Ming Guo*, Nickel catalyzed alkylation of N-aromatic heterocycles with Grignard reagents through direct C-H bond functionalization, Chem. Commun, 2012, DOI:10.1039/C2CC32396F. [4] Peng-Yang Xin, Hong-Ying Niu, Gui-Rong Qu,* Rui-Fang Ding, Hai-Ming Guo*Nickel-Catalyzed sp2 C-H Bonds Arylation of N-Aromatic Heterocycles with Grignard Reagents at Room Temperature Chem. Commun 2011, 47, 11140-11142. [5] Hai-Ming Guo*TtengFei-Yuan Hong-Ying Niu, JinYing-Liu , Run-Ze Mao Gui-Rong Qu,* , Highly Enantioselective Synthesis of Designed Chiral Acyclonucleosides and Acyclonucleotides via Organocatalytic Aza Michael Addition Chem. Eur. J. 2011, 17: 4095–4098 [6] Hai-Ming Guo*Wei-Hao Rao Hong-Ying Niu, Li-Li Jiang ,Ge-Meng, Jia-Jia Jin Xi-Ning Yang, Gui-Rong Qu,* Palladium-Catalyzed C-H Bond Functionalization of C6-Arylpurines, chemical communications2011, 47, 5608-5610 [7] Gui-Rong Qu,*TtengFei-Yuan Hong-Ying Niu, Xin Jin, Xiao-Ting Guo, Xi-Ning Yang, Hai-Ming Guo* Microwave Promoted Palladium-Catalyzed Suzuki-Miyaura Cross-Coupling Reactions of 6-Chloropurines with Sodium Tetraarylborate in Water, Tetrahedron 2011, 47, 9099-9103 [8] Hai-Ming Guo*, Li-Li Jiang , Hong-Ying Niu,Wei-Hao Rao Lei Liang, , Run-Ze Mao ,De-Yang Li, Gui-Rong Qu,*Pd(II)-Catalyzed Ortho Arylation of 6-Arylpurines with Aryl Iodides via Purine-Directed C−H Activation: A New Strategy for Modification of 6-Arylpurine Derivatives, Organic Letters2011, 13(8), 2008–2011 [9] Hong-Ying Niu, Chao Xia, Gui-Rong Qu*, Shan Wu, Yi Jiang, Xin Jin, Hai-Ming Guo*, Microwave Promoted One-Pot Synthesis of 4-Nitrobenzylthioinosine Analogues Using Thiourea as a Sulfur Precursor, Chem. Asian J., 2012, 7, 45-49. [10] Jia-Jia Jin, Hong-Ying Niu, Gui-Rong Qu, Hai-Ming Guo,* John S. Fossey*, Copper-catalysed addition of -alkyl azaarenes to ethyl glyoxylate via direct C(sp3)-H activation, RSC Adv., 2012, DOI:10.1039/C2RA20627G. [11] Gui-Rong Qu*, Ran Xia, Xi-Ning Yang, Jian-Guo Li, Dong-Chao Wang, Hai-Ming Guo* Synthesis of Novel C6-phosphonated Purine Nucleosidis Under Microwave Irradiation by SNAr-Arbuzov Reaction.J.Org.Chem .2008,73,2416-2419 [12] Gui-Rong Qu*, Bo Ren, Hong-Ying Niu, Zhi-Jie Mao, Hai-Ming Guo*A Novel One-step Method for The Synthesis of C-5-substituted O6,5’-Cyclopyrimidine Nucleoside Analogues In Ammonia Water. J.Org.Chem 2008,73,2450-2453 [13] Gui-Rong Qu*, Lin Zhao, Dong-Chao Wang, Jing Wu, Hai-Ming Guo*Microwave-Promoted Efficient Synthesis of C6-cyclo Secondary Amine Substituted Purine Analogues in Neat Water,Green Chem. 2008, 10, 287-289 [14] Gui-Rong Qu*, Zhi-Jie Mao, Hong-Ying Niu, Dong-Chao Wang, Chao Xia, Hai-Ming Guo*,Straightforward and Highly Efficient Catalyst-Free One-Step Synthesis of 2-(Purin-6-yl)acetoacetic Acid Ethyl Esters, (Purin-6-yl)acetates, and 6-Methylpurines through SNAr-Based Reactions of 6-Halopurines with Ethyl Acetoacetate, Org. Lett. 2009, 11 (8), 1745-1748. [15] Gui-Rong Qu*, Jing Wu, Yan-Yan Wu, Feng Zhang Hai-Ming Guo*,Synthesis of novel 6-[N, N-bis(2-hydroxyethyl)amino]purine nucleosides under microwave irradiation in neat water, Green Chem., 2009, 11, 760-762. [16] Hai-Ming Guo*, Peng-Yang Xin, Hong-Ying Niu, Dong-Chao Wang, Yi Jiang, Gui-Rong Qu*,Microwave Irradiated C6-Functionalization of 6-Chloropurine Nucleosides with Various Mild Nucleophiles under Solvent-Free Condition, Green Chem., 2010, 12, 2131-2134. [17] Hai-Ming Guo*, Pu Li, Hong-Ying Niu, Dong-Chao Wang, Gui-Rong Qu*,Direct Synthesis of 6-Arylpurines by Reaction of 6-Chloropurines with Activated Aromatics, J. Org. Chem,2010, 75, 6016-6018. [18] Hai-Ming Guo*, Yan-Yan Wu, Hong-Ying Niu, Dong-Chao Wang, Gui-Rong Qu*,Synthesis of Acyclic Nucleosides with a Chiral Amino Side Chain by the Mitsunobu Coupling Reaction, J. Org. Chem, 2010, 75, 3863-3866. [19] Hai-Ming Guo,a,* Chao Xia,a Hong-Ying Niu,b Xiao-Ting Zhang,a Si-Nan Kong,a Dong-Chao Wang, and Gui-Rong Qua,* Intermolecular Hydrogen Abstraction Reaction between Nitrogen Radicals in Purine Rings and Alkyl Ethers: A Highly Selective Method for the Synthesis of N-9 Alkylated Purine Nucleoside Derivatives. Adv. Synth. Catal. 2011, 353, 53 – 56 [20] Hai-Ming Guo*, Jing Wu, Hong-Ying Niu, Dong-Chao Wang, Feng Zhang, Gui-Rong Qu*,Synthesis of Novel Fluorescent Purine analogues Modified by Azacrown Ether at C6, Bioorg. Med. Chem. Lett., 2010, 20, 3098-3102. 专利成果:
(1)渠桂荣,董春红,杨西宁,蔡玉瑛,田郑刚,郭海明,王秀强 专利名称:化学合成法生产腺苷的工艺 授权时间:2005.01 授权编号:ZL 01127525.1 (2)渠桂荣,杨西宁,申艳红,董春红,郭海明,王秀强,王东超 专利名称:化学合成法生产胞苷的工艺 授权时间:2009.05 授权编号:ZL200710053853.1 (3)渠桂荣,杨西宁,郭海明,蔡玉瑛,何元庆,王秀强,徐绍红,李建平 专利名称:化学合成法生产2,6-二氯嘌呤核苷的工艺 授权时间: 2009.02 授权编号: ZL 200710053919.7 (4)郭海明,渠桂荣,吴静,王东超,杨西宁,张新迎,牛红英,夏然,王菲菲,蔡玉瑛,王秀强 专利名称:具有抗癌活性的6-位被单氮杂冠醚修饰的嘌呤核苷类新化合物及制备方法 授权时间:2010.12 授权编号:No 200910064796.6 奖励:
(1)渠桂荣等《系列核苷生产新工艺》2007年获国家科技进步二等奖。 (2)渠桂荣等《化学法生产腺苷的工艺》2006年获中国发明专利奖优秀奖。 (3)渠桂荣*,赵琳,王东超吴静,郭海明发表在Green Chem. 2008,10,295-29上的论文:Microwave-Promoted Efficient Synthesis of C6-cyclo Secondary Amine Substituted Purine Analogus In neat Water,2010年获河南省自然 科学优秀论文一等奖。 (4)渠桂荣*,夏然,郭海明,杨西宁,王东超发表在 J.Org.Chem 2008,73,2416-2419 上的论文:Synthesis of Novel C6-Phosphonated Purine Nucleosides under Microwave Irradiation by SNAr-Arbuzov Reaction 2010年获河南省自然科学优秀论文二等奖。 (5)渠桂荣*,任博,牛红英 毛志杰,郭海明,发表在 J.Org.Chem 2008,73,2450-2453 的论文:A Novel One-Step Method for the Synthesis of C-5-substituted O6,5′-cyclopyrimidine Nucleoside Analogues in Ammonia Water 2010年4月,获得河南省自然科学优秀论文奖,二等奖。 (6)渠桂荣,毛志杰,牛红英,王东超发表在的论文Straightforward and Highly Efficient Catalyst-Free One-Step Synthesis of 2-(Purin-6-yl)acetoacetic Acid Ethyl Esters, (Purin-6-yl)acetates, and 6-Methylpurines through SNAr-Based Reactions of 6-Halopurines with Ethyl Acetoacetate, 2011年1月,获得河南省自然科学优秀论文奖,一等奖。 |