柴国利，女，博士，硕士生导师，讲师
联系方式：guolichai@126.com
教育经历：
2014/09-2017/12 中国科学院上海有机化学研究所 有机化学 理学博士 导师：黄乃正
2011/09-2014/07 大连理工大学 应用化学 工学硕士
2007/09-2011/07 信阳师范学院 化学 理学学士
工作经历：
2023-06 至今 威尼斯wns8885566 抗病毒性传染病创新药物全国重点实验室 讲师
2018-01 至 2023-05 威尼斯wns8885566 化学化工学院 讲师
研究领域与兴趣：
1.功能有机分子的设计与合成
2.不对称催化
近年来主持的主要科研项目：
1.河南省自然科学基金-青年科学基金项目（232300421371, 2023.01-2024.12）
2.河南省高等学校重点科研项目（21A150028, 2021.01-2022.12）
3.威尼斯wns8885566国家级科研项目培育基金-青年培育（2020PL20, 2020.01-2022.12）
4.威尼斯wns8885566博士科研启动课题（qd18005, 2019.01-2021.09）
代表性论文：
(16) Ya-Jing Hou, Yang-Ling Wang, Junbiao Chang,* Guo-Li Chai.*Chiral Binaphthol-Catalyzed Enantioselective Conjugate Addition of Alkenyl and Arylboronic Acids to α,β-Unsaturated Cyclic N‑Sulfonyl Ketimines. J. Org. Chem. 2024, 89(18), 13137–13149.
(15) Guo-Li Chai,* Xiao Wang, Wei-Yu Huang, Ya-Jing Hou, Junbiao Chang.* Chiral-Boron Complex-Catalyzed Asymmetric [3 + 2] Cycloaddition of 2′-Hydroxychalcones with N‑2,2,2-Trifluoroethylisatin Ketimines. J. Org. Chem. 2024, 89(16), 11607–11619.
(14) Ya-Jing Hou, Lu Zhao, Guo-Li Chai,* Kangbao Zhong,* Junbiao Chang.* Highly Enantioselective Chiral Diol-Catalyzed Conjugate Addition of Boronic Acids to α,β-Unsaturated Trifluoromethyl Ketones. J. Org. Chem. 2023, 88(24), 17461–17471.
(13) Rui-Hao Liu, Guo-Li Chai,* Xiao Wang, Hong-Yu Deng, Junbiao Chang.* Chiral-Boron-Complex-Catalyzed Asymmetric [3 + 2] Cycloaddition of β‑Trifluoromethyl α,β-Unsaturated Ketones with N,N′‑Cyclic Azomethine Imines. J. Org. Chem. 2023, 88(23), 16566–16580.
(12) Guo-Li Chai,*# Xiao Wang,# Ya-Jing Hou, Wen-Hui, Ren, Junbiao Chang.* Chiral-Boron-Complex Catalyzed Asymmetric Inverse-Electron-Demand Aza-Diels−Alder Reaction of β Trifluoromethyl α,β-Unsaturated Ketones with Cyclic N Sulfonyl Ketimines. Org. Lett. 2023, 25(38), 6982–6986.
(11) Xiao Wang, Guo-Li Chai,* Ya-Jing Hou, Ming-Qian Zhou, Junbiao Chang.* Enantioselective Synthesis of Chiral Organosilicon Compounds by Organocatalytic Asymmetric Conjugate Addition of Boronic Acids to β Silyl-α,β-Unsaturated Ketones. J. Org. Chem. 2023, 88(5), 3254–3265.
(10) Guo-Li Chai,*# En-Ze Yao,# Rui-Hao Liu, Junbiao Chang.* Chiral-Boron-Complex-Catalyzed Asymmetric [3 + 2] Cycloaddition of 2′-Hydroxychalcones with N,N′ Cyclic Azomethine Imines. Org. Lett. 2022, 24(35), 6449–6454.
(9) Guo-Li Chai,* Ping Zhang, En-Ze Yao, Junbiao Chang.* Enantioselective Conjugate Addition of Boronic Acids to α,β-Unsaturated 2-Acyl Imidazoles Catalyzed by Chiral Diols. J. Org. Chem. 2022, 87(14), 9197–9209.
(8) En-Ze Yao, Guo-Li Chai,* Ping Zhang, Bo Zhu, Junbiao Chang.* Chiral dihydroxytetraphenylene-catalyzed enantioselective conjugate addition of boronic acids to β-enaminones. Org. Chem. Front. 2022, 9(9), 2375–2381.
(7) Lu Zhao,# En-Ze Yao,#Guo-Li Chai,* Shi-Yu Ma, Junbiao Chang.* Organocatalyzed Enantioselective Conjugate Addition of Boronic Acids to β,γ-Unsaturated α-Ketoesters. J. Org. Chem. 2021, 86(24), 18211–18223.
(6) Ping Zhang, Guo-Li Chai,* En-Ze Yao, Li-Xiao Guo, Xue-Yu Liu, Junbiao Chang.* Asymmetric Double-Conjugate Addition of Alkenylboronic Acids to Dienones Catalyzed by Chiral Diols. Org. Chem. Front. 2021, 8(7), 1575–1580.
(5) Guo-Li Chai,* Yan Qiao, Ping Zhang, Rong Guo, Juan Wang, Junbiao Chang.* Chiral Hydroxytetraphenylene-Boron Complex-Catalyzed Asymmetric Diels-Alder Cycloaddition of 2'-Hydroxychalcones. Org. Lett. 2020, 22(20), 8023–8027.
(4) Guo-Li Chai,* A-Qiang Sun, Dong Zhai, Juan Wang, Wei-Qiao Deng, Henry N. C. Wong, Junbiao Chang. Chiral Hydroxytetraphenylene-Catalyzed Asymmetric Conjugate Addition of Boronic Acids to Enones. Org. Lett. 2019, 21(13), 5040–5045.
(3) Guo-Li Chai, Bo Zhu, Junbiao Chang.* Synthesis and Application of Substituted 1,16-Dihydroxytetraphenylenes in Catalytic Asymmetric Allylboration of Ketones. J. Org. Chem. 2019, 84(1), 120–127.
(2) Guo-Li Chai, Jian-Wei Han, Henry N. C. Wong.*Asymmetric Darzens Reaction of Isatins with Diazoacetamides Catalyzed by Chiral BINOL-Titanium Complex. J. Org. Chem. 2017, 82(23), 12647–12654.
(1) Guo-Li Chai, Jian-Wei Han, Henry N. C. Wong.* Hydroxytetraphenylenes as Chiral Ligands: Application to Asymmetric Darzens Reaction of Diazoacetamide with Aldehydes. Synthesis 2017, 49(1), 181–187.